Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

Key Points

• Tissue-resident memory T cells enhance immunosurveillance in the skin through epithelial interactions.
• Key evidence includes the identification of specific epithelial and sympathetic factors aiding T cell function.
• Observational analysis focusing on tissue structure and immune cell behavior within the skin microenvironment shows complex dynamics.
• Findings suggest a critical role of crosstalk between sympathetic pathways and epithelial cells for immune responses.