March 3, 2026Open Access

Elevated preoperative inflammatory ratios (NLR/PLR) predict adverse pathology and poor surgical outcomes in metastatic renal cell carcinoma: a retrospective analysis

Key Points

Poor surgical outcomes correlate with elevated NLR and PLR in metastatic renal cell carcinoma.
Clinical stage III-IV and Fuhrman grade 3-4 indicate unfavorable pathology at surgery.
Retrospective analysis of patients highlights the importance of preoperative inflammatory ratios.
Elevation of NLR (≥2.76) and PLR (≥166.50) suggests increased risk of complications during surgery.

Abstract

NLR and PLR, showing up-regulated expression in mRCC, correlate intimately with advanced clinical staging and higher Fuhrman grading. Clinical stage III-IV, Fuhrman grade (3-4), elevated NLR (≥2.76), and high PLR (≥166.50) are predictors of unfavorable surgical outcomes in mRCC.

Elevated preoperative inflammatory ratios (NLR/PLR) predict adverse pathology and poor surgical outcomes in metastatic renal cell carcinoma: a retrospective analysis

Key Points

Abstract

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