VKORC1L1 Downregulation Induced Vitamin K Cycle Disorder Exacerbates Neuronal Ferroptosis After Spinal Cord Injury

Key Points

• Neuronal ferroptosis is exacerbated after spinal cord injury due to VKORC1L1 downregulation.
• The study reveals alterations in the vitamin K cycle linked to neurodegeneration after injury.
• Assessment using cellular models demonstrates the relationship between VKORC1L1 and neuronal health.
• Insights into VKORC1L1's role call for further investigation into potential therapeutic strategies.