March 3, 2026Open Access

Circulating exosomal miR-550a-5p/miR-665 identify coronary microvascular dysfunction and drive endothelial–myocyte crosstalk in type 2 diabetes

Key Points

Coronary microvascular dysfunction is linked to exosomal miR-550a-5p and miR-665.
These miRNAs serve as biomarkers, facilitating earlier detection in type 2 diabetes.
The analysis demonstrates the role of exosomal signaling in endothelial-to-cardiomyocyte communication.
Future work will focus on external validation and understanding target networks.

Abstract

Exosomal miR-550a-5p, together with miR-665, functions as a dual-utility signal, serving as an accessible biomarker for coronary MD and as a mechanistic mediator in endothelial-to-cardiomyocyte exosomal signaling. These findings support earlier detection, risk stratification, and mechanism-guided intervention in T2DM. Future priorities include external validation, longitudinal kinetic assessment, and target-network mapping.

Circulating exosomal miR-550a-5p/miR-665 identify coronary microvascular dysfunction and drive endothelial–myocyte crosstalk in type 2 diabetes

Key Points

Abstract

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