Are PFAS alternatives safer? A network toxicology analysis suggests comparable or novel risks for hypertensive disorders of pregnancy

Key Points

• Hypertensive disorders of pregnancy show similar risk profiles between PFAS and their alternatives, indicating potential health concerns.
• The analysis indicates that PFAS alternatives may have comparable or new toxicological risks that require further investigation and monitoring.
• Utilizing a network toxicology approach, this study assessed various biomarkers linked to hypertensive disorders in pregnant individuals.
• This calls for careful evaluation of PFAS alternatives before they are widely adopted in consumer products.