Tapentadol induces progressive hepatic damage via disrupting Hippo–YAP and bile acid–FXR pathways: An integrated experimental and computational perspective

Key Points

• Hepatic damage progresses due to disruptions in hippo and yap pathways caused by tapentadol, which is critical for liver health.
• Key findings indicate significant dysregulation in bile acid metabolism when exposed to tapentadol.
• Integrated experimental and computational methods reveal complex interactions within molecular pathways affected by tapentadol.
• Further investigation is needed to assess long-term implications of tapentadol use on liver function and overall health.