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March 3, 2026
Tauroursodeoxycholic acid alleviates depression-like behavior induced by chronic unpredictable mild stress through amelioration of catecholamine imbalance
NS
Nataša Spasojević
BS
Bojana Stefanovic
HF
Harisa Ferizović
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Key Points
Depression-like behavior is significantly reduced with tauroursodeoxycholic acid treatment, demonstrating its therapeutic potential.
Key evidence shows a notable improvement in behavior scores following treatment with tauroursodeoxycholic acid over a chronic stress period.
Analysis focused on biochemical pathways and behavioral analysis under chronic unpredictable mild stress conditions.
Significance lies in potential advances in depression treatment, although more studies are needed to confirm these findings.
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Spasojević et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75e56c6e9836116a28d48
https://doi.org/https://doi.org/10.1016/j.brainres.2026.150188
Tauroursodeoxycholic acid alleviates depression-like behavior induced by chronic unpredictable mild stress through amelioration of catecholamine imbalance | Synapse