March 3, 2026Open Access

The Association between Hematocrit and All-Cause Mortality in Patients with Acute Congestive Heart Failure

Key Points

A negative association exists between hematocrit levels and 365-day all-cause mortality in patients with acute heart failure.
Multivariable Cox regression identified hematocrit as an independent protective factor for mortality with a hazard ratio of 0.98.

Structured PICO

Does admission hematocrit level affect 365-day all-cause mortality in patients with acute heart failure?

Population

2,193 patients with acute heart failure (AHF) extracted from the MIMIC-IV database.

Intervention

Hematocrit (HCT) levels at admission (categorized as low < 30%, middle 30% - 40%, and high ≥ 40%)

Comparator

Comparisons across different HCT groups (low, middle, high)

Outcome

365-day all-cause mortalityhard clinical

Admission hematocrit has a non-linear, negative association with 365-day all-cause mortality in acute heart failure, with levels below 30% indicating significantly higher mortality risk.

Abstract

Hematocrit (HCT) has clinical significance in the prognosis of acute heart failure (AHF). This study investigated the association between HCT and 365-day all-cause mortality rate from the MIMIC-IV database. We also explored the specific inflection point for HCT that affects the varying clinical prognoses in patients with AHF.A total of 2,193 patients with AHF were extracted from the MIMIC-IV database. Patients were divided into 3 groups based on HCT levels at admission: low-HCT ( 0.05).A negative association exists between HCT and 365-day all-cause mortality in patients with AHF. Low HCT (< 30%) was significantly associated with a higher mortality rate in patients with AHF.

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Cite This Study

Ren et al. (Fri,) studied this question.

synapsesocial.com/papers/69a75e8bc6e9836116a293d1 https://doi.org/https://doi.org/10.1536/ihj.25-187

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