Sex differences in self-reported symptoms and comorbidities associated with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: A retrospective study

Key Points

• Females with hypermobile Ehlers-Danlos syndrome report a greater burden of symptoms than males, indicating potential sex differences.
• The research highlights that males are underrepresented in demographics, with implications for diagnosis and treatment.
• A retrospective analysis was conducted to explore symptoms and comorbidities in hypermobile individuals by gender.
• These findings call for further investigation into the pathogenic drivers influencing symtomatology and male-female discrepancies.