Icariin protects against cisplatin-induced renal injury and ferroptosis via JNK pathway in mice

Key Points

• Icariin significantly reduces renal injury associated with cisplatin treatment, enhancing kidney function in mice.
• Key evidence indicates that renal protective effects were confirmed by measuring oxidative stress markers in treated mice.
• Study includes analysis of the JNK pathway's role in preventing ferroptosis-induced kidney damage following cisplatin exposure.
• May enable new therapeutic approaches to protect kidney function during cancer chemotherapy, improving patient outcomes.