Potential neuroprotective role of pregabalin in oxygen glucose deprivation induced neural stem cells

Key Points

• Pregabalin treatment enhances cell survival under oxygen glucose deprivation conditions, indicating its potential neuroprotective effects.
• A significant increase in neural stem cell viability is observed with pregabalin compared to controls, suggesting an efficacy against apoptosis.
• Assessment using various cellular assays reveals a decrease in neuroinflammation and an increase in neurogenesis metrics after pregabalin exposure.
• These findings support the exploration of pregabalin as a treatment strategy in neural injury models, warranting further investigation.