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Maintaining “motor reserve” through physical activity and medication to mitigate motor decline in Parkinson’s disease | Synapse
March 3, 2026
Maintaining “motor reserve” through physical activity and medication to mitigate motor decline in Parkinson’s disease
KT
Kazuto Tsukita
AK
Akihiro Kikuya
EN
Etsuro Nakanishi
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Key Points
Motor decline can be mitigated through sustained physical activity and medication, preserving motor reserve.
Patients engaging in regular exercise showed improved motor function and less decline over time.
Assessment of motor reserve highlights the importance of these interventions in managing Parkinson's disease.
May enable better management of Parkinson’s symptoms, but further research is needed for broader applications.
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Tsukita et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75f8cc6e9836116a2afe8
https://doi.org/https://doi.org/10.1016/j.jns.2025.124241