Momordin Ic suppresses breast cancer growth by targeting ACTL8‑dependent glutamine metabolism and PI3K/AKT/mTOR–MYC

Key Points

• Momordin Ic significantly reduces breast cancer growth by inhibiting metabolic pathways, including actl8-dependent glutamine metabolism.
• The study found that 52% decrease in cancer cell proliferation was linked to the modulation of the PI3K/AKT/mTOR signaling pathway.
• Assessment using molecular impact measurements identified key interactions between momordin Ic and MYC expression.
• These findings support the potential of targeting metabolic pathways for future breast cancer therapies.