March 3, 2026Open Access

ACADL and ADH1B signify ketone body metabolic reprogramming in osteoarthritic synovium: insights from bioinformatics and animal model studies

Key Points

ACADL and ADH1B are linked to metabolic reprogramming in osteoarthritis synovium, impacting immune responses.
The use of a nomogram shows improved accuracy in early osteoarthritis diagnosis, enhancing treatment strategies.

Structured PICO

Population

Osteoarthritic synovium (bioinformatics and animal model)

Outcome

Role of ACADL and ADH1B in ketone body metabolic reprogramming and immune dysregulation

ACADL and ADH1B are identified as key genes linking ketone body metabolism to immune dysregulation in osteoarthritis, offering potential new therapeutic targets.

Abstract

ACADL and ADH1B link KBM abnormalities to immune dysregulation in the OA synovium. The nomogram enables the precise early diagnosis of OA, and progesterone and fomepizole are promising targeted therapies. These findings deepen the current understanding of OA pathogenesis and support the advancement of personalized treatments for clinical translation.

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Cite This Study

Li et al. (Tue,) studied this question.

synapsesocial.com/papers/69a7600dc6e9836116a2c737 https://doi.org/https://doi.org/10.3389/fmed.2026.1700784

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