Intrathecal Chemotherapy and Steroids for ICANS after CAR-T: A Single-Center Retrospective Review

Key Points

• Intrathecal chemotherapy effectively reduces the severity of ICANS following CAR-T therapy, improving patient outcomes.
• In this review, 30 patients treated for neurotoxicity after CAR-T received various interventions, achieving significant symptom relief.
• Retrospective analysis on 30 cases revealed a notable improvement in symptoms following intrathecal chemotherapy and steroid treatment.
• This approach highlights the potential for better management strategies in CAR-T related neurotoxicity, though further studies are needed.