Muscarinic 3 receptor antibodies in Sjögren's disease: Evaluating assay variability and detection methods

Key Points

• Muscarinic 3 receptor antibodies are frequently detected in Sjögren's disease, highlighting their potential role as biomarkers.
• Assay variability was significant, with different methods yielding inconsistent results in antibody detection.
• Assessment using multiple detection methods revealed substantial differences in sensitivity and specificity for identifying antibodies.
• Implications for clinical diagnostics underscore the need for standardization to enhance reliability in Sjögren's syndrome diagnosis.