Clinical Impact of Familial Hypercholesterolemia on Lower Extremity Artery Disease in Premature Patients | Synapse
March 3, 2026Open Access
Clinical Impact of Familial Hypercholesterolemia on Lower Extremity Artery Disease in Premature Patients
Key Points
Poor outcomes are linked to familial hypercholesterolemia in lower extremity artery disease patients.
15% of premature patients with lower extremity artery disease showed familial hypercholesterolemia.
Routine screening for familial hypercholesterolemia and evaluating Achilles tendons are recommended for better prognosis.
Implications highlight the need for increased awareness and early detection of familial hypercholesterolemia.
Abstract
FH was present in 15% of pLEAD patients and associated with poor outcomes. Routine FH screening, including pCAD history and Achilles tendon evaluation, may improve prognosis.