An enigmatic case of primary refractory myeloma: Mystery solved

Key Points

• Primary refractory myeloma demonstrates unresolved therapy resistance, complicating effective treatment options.
• Key biomarker analysis identified significant genetic mutations associated with therapy resistance in this case.
• Assessment using advanced genetic profiling revealed distinct molecular pathways contributing to refractory myeloma.
• Understanding these pathways may enable targeted therapies, improving outcomes for similar cases in the future.