Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects

Key Points

• Cognitive intervention significantly preserves brain function in aging TgF344-AD rats, suggesting neuroprotective effects.
• Improvements noted in both male and female rats emphasize the importance of sex-specific responses to cognitive intervention.
• Assessment using behavioral tests showed marked changes in neuronal health across the intervention group compared to controls.
• Findings highlight the potential of early-life cognitive strategies for brain health, warranting further exploration in clinical settings.