Two integument-enriched chemosensory proteins contribute to deltamethrin tolerance through cuticular binding in Locusta migratoria

Key Points

• Deltamethrin tolerance is enhanced through specific chemosensory proteins in Locusta migratoria, indicating a novel resistance mechanism.
• Key proteins show significant cuticular binding, allowing the locusts to effectively tolerate the effects of deltamethrin, an important insecticide.
• Analysis of chemosensory protein interactions suggests that these proteins play a critical role in insecticide resistance strategies.
• Highlighting the need for alternative pest management approaches, findings may inform the development of new insecticide formulations.