Age and the relation of common neuropathologies to dementia in Brazilian adults

Key Points

• Dementia is commonly associated with mixed neuropathologies in older adults, suggesting complex underlying mechanisms.
• In young adults, chronic gross infarcts are frequently related to dementia, rather than Alzheimer's Disease pathology.
• The analysis was based on a community-based, clinical-pathologic study involving over 5300 collected brain samples.
• These findings may highlight the need for early intervention strategies to address emerging pathologies in young adults.

Abstract