Design, synthesis and biological evaluation of novel fluoroquinolone-uracil hybrids against methicillin-resistant Staphylococcus Epidermidis (MRSE) infections

Key Points

• Fluoroquinolone-uracil hybrids exhibit potent activity against methicillin-resistant Staphylococcus epidermidis infections.
• The lead compound demonstrated a minimum inhibitory concentration of 0.5 µg/mL, indicating strong antibacterial potential.
• Synthesis involved multi-step chemical reactions to create the targeted hybrid compounds effectively.
• Novel hybrids offer insights into alternative treatments for MRSE infections, highlighting the need for new antibiotic strategies.