Xiao-Chaihu-Tang preserves intestinal barrier and ameliorates irinotecan-evoked delayed diarrhea by anchoring endogenous tryptophol to modulate inflammation and oxidation dependent on AhR-UGT1A1-microbiota axis

Key Points

• Improved intestinal barrier function was observed after treatment with Xiao-Chaihu-Tang.
• The reduction in delayed diarrhea was significantly linked to the modulation of inflammation and oxidation.
• Analysis using microbial and biochemical assessments highlighted the role of tryptophol and the AhR-UGT1A1 pathway.
• These findings suggest a potential therapeutic application for managing irinotecan-induced complications.