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The effect of substrate and product transfer between polydisperse microdroplets on biological high-throughput screens | Synapse
March 3, 2026
Open Access
The effect of substrate and product transfer between polydisperse microdroplets on biological high-throughput screens
TF
T. Fecker
TK
T. de Kanter
RT
R. J. van Tatenhove-Pel
Key Points
Substrate and product transfer enhances the effectiveness of biological high-throughput screens, facilitating better results.
Experiments demonstrated shifts in reaction dynamics in polydisperse microdroplets observed under controlled conditions.
Assessment using microdroplet technology showcases interactions between various substrates and products in biological assays.
Improved understanding of transfer mechanisms may advance methodologies in high-throughput screening applications.
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Fecker et al. (Mon,) studied this question.
synapsesocial.com/papers/69a76566badf0bb9e87d8f51
https://doi.org/https://doi.org/10.1038/s41598-025-25878-5