March 3, 2026Open Access

A selective Cullin 3 RING E3 ligase inhibitor attenuates hyperglycemia via dual insulin sensitizing and insulinotropic action

Key Points

Hyperglycemia decreases significantly due to selective inhibition of Cul3, enhancing insulin response.
Cul3 inhibition leads to both insulin sensitization and secretion effects, crucial for regulating blood sugar levels.
Analysis of the effects shows that cullin pan neddylation inhibitors can effectively target hyperglycemia mechanisms.
Further understanding is needed for clinical application, particularly regarding long-term effects.

Abstract

a. Pan cullin neddylation inhibitors exhibit potent hypoglycemic effect.b. The target organs and mechanisms underlying the hypoglycemia effect of cullin pan neddylation inhibitors are incompletely understood.c. We found that inhibition of Cul3 leads to a dual insulin sensitization and insulinotropic effect.d. Selective inhibition of Cul3 neddylation is a feasible approach to lower hyperglycemia.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Lijie Gu

Lei Xiong

Mohammad Hasan

Actions

Institutions

University of Oklahoma Health Sciences Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

A selective Cullin 3 RING E3 ligase inhibitor attenuates hyperglycemia via dual insulin sensitizing and insulinotropic action

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider