Gastric cancer remains a leading cause of global cancer mortality, with limited advances in its prevention and treatment owing to an incomplete understanding of its pathogenesis. Among the key precancerous lesions, spasmolytic polypeptide-expressing metaplasia has emerged as a critical driver in gastric carcinogenesis. This review summarizes the recent advances in the mechanistic roles of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases. By elucidating these pathways, this review sought to provide novel insights that could inform future strategies for early intervention and prevention of gastric cancer.
Yang et al. (Mon,) studied this question.