Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management

Key Points

• Patients with temporomandibular disorders often experience comorbid pain-affective disorders, complicating treatment.
• Key findings indicate that around 40% of patients report significant emotional distress related to pain symptoms.
• Analysis focused on neurobiological mechanisms and pain modulation pathways that contribute to this comorbidity.
• Highlighting the need for integrated treatment approaches, this study addresses the complexity of managing related disorders.