Involvement of gut microbiota in sub-chronic chlorantraniliprole-induced metabolic alteration in chironomid larvae (Propsilocerus akamusi): Evidence from multi-omics, histopathological and biochemical analysis

Key Points

• Metabolic alterations were observed in chironomid larvae after exposure to chlorantraniliprole, suggesting gut microbiota's role.
• The study highlighted significant changes in metabolic profiles and histopathological conditions following larval exposure.
• A multi-omics approach facilitated comprehensive insights into the biochemical changes related to gut microbiota.
• These findings call for further exploration of environmental contaminants and their effects on aquatic ecosystems.