March 3, 2026Open Access

Comparison of 2005 and 2024 diagnostic criteria for early identification of pediatric sepsis and septic shock in PICU patients: a prospective cohort study

Key Points

Improved specificity under 2024 criteria may delay early diagnosis and treatment of septic shock.
2024 diagnostic criteria focus on strict definitions of septic shock, impacting timely patient care.
Observational analysis of pediatric patients suggests a need for prospective studies to enhance early identification.
AI-supported early warning models are essential in addressing diagnostic limitations for pediatric sepsis.

Abstract

The 2024 sepsis criteria improve specificity but may overlook early septic shock. The 2024 septic shock criteria are stricter, potentially delaying diagnosis and treatment. Prospective studies and AI-supported early warning models are needed for better early identification and outcomes.

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Discussion

Journals

Frontiers in Pediatrics

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Capital Institute of Pediatrics

References and Citations

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