Discovery of mangiferin lipophilic amide derivatives as novel fatty acid synthase inhibitors with potent anti-hepatocellular carcinoma activity

Key Points

• Novel mangiferin lipophilic amide derivatives effectively inhibit fatty acid synthase, showing strong anti-cancer effects.
• In vitro tests demonstrate over 75% inhibition of fatty acid synthase activity with specific derivatives.
• Experimental analysis focused on evaluating the potency of derivatives in targeting liver cancer cells.
• Highlights potential therapeutic avenues in targeting fatty acid synthase to combat hepatocellular carcinoma.