Da-Bu-Yin-Wan rescues cognitive deficits in aging and Alzheimer’s disease models by Wnt/β-catenin-dependent restoration of lysosomal acidification

Key Points

• Cognitive deficits improve significantly, particularly in models of aging and Alzheimer's disease, showing potential therapeutic value.
• Wnt/beta-catenin pathway activation enhances lysosomal acidification and cognitive function in aged subjects.
• Analysis of various Alzheimer’s disease models demonstrates the effectiveness of Da-Bu-Yin-Wan on cognitive restoration.
• These findings highlight the need for further investigations into lysosomal function as a target for age-related cognitive decline and Alzheimer's.