Chemogenetic modulation of CNS pericytes: Impact on pericyte Ca2+ dynamics, CBF, BBB, and Alzheimer’s disease progression in mice

Key Points

• Altered calcium dynamics lead to significant changes in cerebral blood flow during Alzheimer's disease progression.
• In vivo assessment showed a 40% increase in pericyte Ca2+ levels, impacting blood-brain barrier integrity.
• Chemogenetic modulation of CNS pericytes was employed to evaluate changes in blood flow metrics in live mice.
• Findings indicate disruptions in calcium signaling may contribute to Alzheimer's disease effects on brain health.