March 3, 2026Open Access

PPARa-FSP1 axis modulates lipid peroxidation-induced neuronal ferroptosis to promote functional recovery in mouse model of traumatic spinal cord injury

Ferroptosis significantly influences neuronal recovery after spinal cord injury, promoting functional improvement.
Key finding shows the PPARa-FSP1 axis plays a critical role in reducing lipid peroxidation and neuronal death.
Analysis used a mouse model to investigate the relationship between lipid peroxidation and neuronal recovery mechanisms.
Findings suggest novel therapeutic strategies focusing on lipid metabolism for spinal cord injury recovery.

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