Systems medicine approach unravels MMP2 and NOTCH3 as key mediators of cigarette smoke-induced airway remodelling in COPD

Key Points

• Airway remodelling is significantly impacted by MMP2 and NOTCH3 mediators.
• Key findings suggest that cigarette smoke exposure increases levels of MMP2 and NOTCH3.
• Observational analysis of airway tissues highlights the molecular pathways involved in COPD.
• Research indicates potential pathways for targeted interventions in treating COPD.