Tianwangbuxiandan decoction alleviates constipation and associated emotional disorders via regulating the brain-gut axis: Involving MAPK/ERK/JNK signaling pathways

Key Points

• Constipation symptoms significantly improved along with associated emotional disorders during treatment.
• The treatment showed notable efficacy in regulating the brain-gut axis via MAPK and JNK pathways.
• Observational analysis across multiple assessments indicates powerful regulatory effects of the decoction on emotional well-being.
• Findings highlight the potential for herbal treatments to impact both gut health and emotional states, suggesting a holistic approach.