Pharmacological potential of chalepensin from Ruta chalepensis L.: Acute toxicity and in vivo antitumor activity in the L5178Y-R murine model

Key Points

• Chalepensin demonstrated significant antitumor activity in the L5178Y-R murine model, indicating its potential efficacy against tumors.
• Acute toxicity assessment showed minimal adverse effects, supporting its safety for further studies.
• In vivo analysis involved administering chalepensin to evaluate its impact on tumor growth over a defined period.
• Findings highlight the pharmacological benefits of chalepensin, suggesting it may be a valuable candidate for cancer treatment.