March 3, 2026Open Access

Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway

Key Points

Mitochondrial calcium overload correlates with decreased survival in bladder cancer patients, highlighting its importance.
Downregulation of ATP2B4 resulted in increased apoptosis rates in bladder cancer cells, demonstrating its role in cell survival.
Genetic signature based on calcium signaling genes effectively predicts therapeutic response in bladder cancer cases, enhancing clinical decision-making.
Analysis identifies VDAC1 and MCU as critical components in calcium regulation, with potential therapeutic implications.

Abstract

Collectively, we have developed a unique genetic signature that is based on genes associated with calcium signaling. This signature possesses the capacity to precisely anticipate the survival prognosis and therapeutic response of BLCA patients and might have a crucial role in guiding clinical treatment. Furthermore, ATP2B4 has been identified as a crucial oncogenic gene. The downregulation of ATP2B4 leads to mitochondrial Ca2+ overload, ultimately resulting in apoptosis of BLCA cells.

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Cite This Study

Zhang et al. (Fri,) studied this question.

synapsesocial.com/papers/69a76775badf0bb9e87e0fe3 https://doi.org/https://doi.org/10.3389/fimmu.2026.1561666

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