Sertoli cell aging: damage accumulation and epigenetic alterations affecting male fertility

Key Points

• Damage accumulation in sertoli cells significantly impacts male fertility.
• Aging-related changes in epigenetics were noted, highlighting a critical mechanism in fertility decline.
• This analysis identified the role of aging in altering sertoli cell function and epigenetic landscape.
• Findings support the potential for targeted therapies to address fertility issues related to male aging.