March 3, 2026Open Access

Using the triglyceride-glucose index and derived indexes to forecast progression from pre-diabetes to diabetes: A 3-year follow-up study

Key Points

The triglyceride-glucose index indicates increased risk for conversion from pre-diabetes to diabetes.
A significant finding shows that the TyG-BMI outperforms other indices in predicting diabetes risk over three years.
This study used longitudinal follow-up to assess the predictive power of several metabolic indices.
Caution is needed in interpreting the modest accuracy of these indicators for clinical decision-making.

Abstract

The TyG index and its derived indicators were risk factors for the pre-diabetes to diabetes outcome, and may be regarded as predictors of the outcome. The risk of conversion of pre-diabetes to diabetes increased with increases in the TyG index and its derived indicators. The TyG-BMI was better than TyG and TyG-WC in predicting the 3-year outcome for diabetes. Although these indices could aid in the initial risk stratification in primary care, their modest accuracy warrants cautious interpretation.

Using the triglyceride-glucose index and derived indexes to forecast progression from pre-diabetes to diabetes: A 3-year follow-up study

Key Points

Abstract

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