Homogentisic Acid Disrupts the Blood–Brain Barrier and Promotes Aβ Aggregation in Alzheimer’s Disease

Key Points

• Homogentisic acid disrupts the blood-brain barrier, leading to neurodegeneration.
• At concentrations of 100μM, Aβ aggregation is promoted significantly by homogentisic acid exposure.
• The study employs in vitro models to assess the effects on cellular integrity and Aβ dynamics.
• Implications suggest that targeting homogentisic acid could help in managing Alzheimer's disease pathology.