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Oxygen dependency of cognition: Neural mechanisms of reversible cognitive changes in Tibetan highlanders during altitudinal migration | Synapse
March 3, 2026
Open Access
Oxygen dependency of cognition: Neural mechanisms of reversible cognitive changes in Tibetan highlanders during altitudinal migration
XL
Xiaoyan C. Li
HL
Hao Li
YZ
Yaping Zeng
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Key Points
Cognitive changes occur in Tibetan highlanders due to variations in oxygen levels, suggesting an adaptive neural mechanism.
Research shows that decreased oxygen on lower altitudes can temporarily impair cognitive function, impacting altitude adaptation.
Observational analysis reveals that neural mechanisms adapt alongside oxygen changes during altitudinal migration.
Findings may enable better understanding of cognitive flexibility among populations in hypoxic environments.
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Li et al. (Fri,) studied this question.
synapsesocial.com/papers/69a767d0badf0bb9e87e2779
https://doi.org/https://doi.org/10.1016/j.neuroimage.2026.121791