March 3, 2026Open Access

Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks

Key Points

DGNTG inhibits synoviocyte proliferation and migration, leading to reduced rheumatoid arthritis symptoms.
Key metric includes the mechanistic evidence based on ceRNA networks derived from MH7A cells.
Assessment using transcriptomic data of DGNTG-treated MH7A cells reveals its mechanism of action.
These findings support potential new treatments for rheumatoid arthritis but need further validation.

Abstract

This study presents evidence that DGNTG exerts anti-RA effects through the inhibition of synoviocyte proliferation, migration and invasion. Additionally, It provided a valuable resource for elucidating the mechanism of action of DGNTG by constructing a competing endogenous RNA network based on transcriptomic data obtained from DGNTG-treated MH7A cells.

Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks

Key Points

Abstract

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