Early Photoreceptor Disruption in Emerging Subretinal Drusenoid Deposits Detected by Adaptive Optics Imaging

Key Points

• Photoreceptor changes occur even before subretinal drusenoid deposits become visible on OCT imaging, highlighting their sensitivity.
• Alterations in photoreceptor optical properties can indicate early structural and functional disruptions during SDD formation.
• Detection is made possible through high-resolution adaptive optics confocal imaging techniques.
• These findings emphasize the importance of early intervention in preserving photoreceptor health.