Synthesis and anticancer activity of parthenolide-based PROTACs for IKKβ degradation

Key Points

• The degradation of IKKβ shows significant anticancer activity against multiple cancer types.
• In vitro results indicate that 75% of the tested cancer cells were sensitive to parthenolide-based PROTACs.
• Assessment using cellular assays demonstrated effective synthesis of PROTACs targeting IKKβ in cancer cells.
• These findings suggest that parthenolide-based PROTACs may advance therapeutic strategies against tumors.