Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort

Key Points

• Late-life cerebrovascular health in women appears to be supported by extended exposure to estrogen.
• The analysis highlights the potential of genotype-specific neuroprotective effects of estrogen on brain health.
• Population-based data from the Gothenburg H70-1944 Birth Cohort informed these findings on hormonal therapy.
• Future research calls for clarifying estrogen's long-term impact on cognition to improve prevention guidelines.