Acknowledgements: We thank Pascale Gaudet, Harold Drabkin, Raymond Lee, Marc Feuermann, the InterPro curators, and other members of the GO consortium for addressing the hundreds of GO tickets and disputes raised during this work. Thanks also to Kristian Axelson for help with EC and RHEA queries, and to Peter Karp and colleagues for help updating FlyCyc. We are grateful to Jason Tennessen and Thom Kaufman for providing feedback on the manuscript.
Phani et al. (Sun,) studied this question.