March 3, 2026Open Access

A 25-year evaluation of direct local international normalized ratio calibration of the Owren type prothrombin time method in Sweden

Key Points

Prothrombin time measurements show high agreement among laboratories, ensuring consistent results across Sweden.
Key evidence shows that no significant differences exist in reagents, indicating enhanced calibration methods.
Assessment of calibration procedures utilized certified plasmas, which improved national PT measurement performance.
Findings suggest that this user-friendly method has maintained measurement stability for decades, warranting further investigation.

Abstract

There is good agreement among PT measurements across Swedish laboratories, with no significant differences in reagents. The user-friendly, unique calibration procedure, including the preparation of certified plasmas, improved the performance of national PT measurements and has been shown to remain stable over decades.

A 25-year evaluation of direct local international normalized ratio calibration of the Owren type prothrombin time method in Sweden

Key Points

Abstract

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