Total flavonoids from Carthamus tinctorius L. inhibit the liver fibrosis progression via Hippo/YAP pathway

Key Points

• Total flavonoids inhibit liver fibrosis progression via the Hippo/YAP pathway, indicating a promising therapeutic route.
• Inhibition was observed with a notable decrease in fibrosis markers in treated samples compared to controls.
• Assessment using liver tissue samples revealed changes in the Hippo pathway activity due to flavonoid treatment.
• Supports the need for further exploration of flavonoids' role in liver health and fibrotic diseases.