Molecular heterogeneity of Glioblastoma-associated microglia and macrophages and myeloid-derived suppressor cells: Insights from single-cell omics and therapeutic implications

Key Points

• Heterogeneity in glioblastoma-associated myeloid cells indicates diverse molecular profiles and potential functional roles.
• The findings highlight the importance of microglia and myeloid-derived suppressor cells in glioblastoma progression and treatment.
• Assessment using single-cell omics provides insights into cellular interactions and variations within glioblastoma microenvironment.
• The implications stress the need for tailored therapies targeting specific myeloid cell subtypes to improve patient outcomes.