Enantioselective Pd&Cu-Catalyzed Coupling of Imine Esters with gem-Difluorinated Cyclopropanes

Key Points

• The study aims to develop an efficient method for synthesizing enantiomerically enriched compounds using a bimetallic catalyst system.
• Utilized a Pd/Cu-cocatalyzed system for the coupling reactions.
• Investigated the reaction with various imine esters and gem-difluorinated cyclopropanes.
• Analyzed reaction outcomes based on substrate variations.
• Successfully accessed α-quaternary 2-fluoroallylic 2H-pyrroles.
• Achieved high enantioselectivity and broad substrate scope.